Explore further Citation: Mozilla lab wants scientists to step out of analog age (2013, June 18) retrieved 18 August 2019 from https://phys.org/news/2013-06-mozilla-lab-scientists-analog-age.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (Phys.org) —Talk about big ideas. Not satisfied to rest on laurels of having brought forth the open source browser Firefox, Mozilla—defined by some as a global project, by others as one of the key open-source movements, is thinking big, really big, about changing the world of scientists. This month Mozilla announced that it is launching the Mozilla Science Lab, with support from the Alfred Sloan Foundation. According to a blog post by Foundation executive director, Marc Surman, Mozilla is creating a Science Lab for researchers around the world. The idea is to enable researchers to more easily (1) be in a virtual place where they share ideas, tools and best practices for using next-generation web solutions to solve problems in science, and (2) to make this an exploration as to how to make research faster, more agile and collaborative. But, here’s the problem. Mozilla is ready to get started, but are scientists ready to get started? Surman wrote, “Scientists created the web—but the open web still hasn’t transformed scientific practice to the same extent we’ve seen in other areas like media, education and business. For all of the incredible discoveries of the last century, science is still largely rooted in the ‘analog’ age.”This is 2013 and the style of scientific work is in a time warp, say critics who wish there was a different type of work environment. The researcher may conduct research and submit findings in the form of a paper to a peer-review journal; upon publication the world will see what was achieved. While developers easily share tips and observations in online community groups that push projects and solutions ahead, scientists elsewhere may feel the pressure of sticking to a publish-the-paper path and hang back from working in a global collaborative environment. The Lab’s team is ready for the challenge. “In scientific research, we’re dealing with special circumstances, trying to innovate upon hundreds of years of entrenched norms and practices, broken incentive structures and gaps in training that are dramatically slowing down the system, keeping us from making the steps forward needed to better society.”A basic step forward will be providing digital literacy for scientists. Sharing, re-using and producing research on the web involves computer skills they may not yet have. Software Carpentry will be a member of the lab team for this purpose. According to the announcement, “As part of the Mozilla Science Lab, Software Carpentry will explore what ‘digital literacy’ means for scientific researchers and how these digital skills can further aid their work.” Kaitlin Thaney is the director of the Mozilla Science Lab.Software Carpentry, a volunteer organization supported by the Alfred P. Sloan Foundation and the Mozilla Foundation, teaches basic computing skills. They operate through two-day boot camps for scientists. Organizations have supported their efforts since they ran their first class at Los Alamos National Laboratory in 1998. Learners are typically graduate students in science, engineering, and medicine who have written a few lines of code either on their own or for a class as undergrads, but are not familiar with practices in scientific computing such as version control or unit testing.) With or without the Mozilla effort, however, there is a sense that scientists are moving toward a collaborative model; at least some scientists believe that it is the obvious way of the future in an Internet-connected world. ResearchGate, the networking site for scientists, is given as an example. ResearchGate began in 2008, by scientists for scientists. Its founders, physicians and a computer scientist, have seen its membership grow considerably. ResearchGate is used by researchers who can present their work, share publications, connect with specialists in their field, ask questions, and get answers about research issues. © 2013 Phys.org Taiwan’s Hon Hai in tie-up with Mozilla More information: www.researchgate.net/ www.nytimes.com/2012/01/17/sci … ?pagewanted=all&_r=0wiki.mozilla.org/ScienceLab
Citation: Linking antibiotic to antibody found able to kill MRSA hiding in mice cells (2015, November 5) retrieved 18 August 2019 from https://phys.org/news/2015-11-linking-antibiotic-antibody-mrsa-mice.html Prior research has found that one of the ways that bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) become resistant to drugs meant to kill them, is by hiding out in host cells, where antibiotics cannot find them. Many in the field believe this is why some bacterial infections return so quickly after antibiotics are stopped. In this new effort, the researchers developed a way to cause a common antibiotic to bind to an antibody until it gets inside a host cell harboring a certain type of bacteria—then, the bond is broken and the antibiotic kills the bacteria.More specifically, they created an anti-S. aureus antibody that grabs onto one type of sugar found on the exterior part of the bacteria. Next, they attached an antibiotic called rifalogue via a linker molecule to cysteines on the antibody. The result was the creation of antibody-antibiotic conjugates, or AACs. Once they make their way inside a certain host cell, the linker molecule is removed releasing the antibiotic to do its job.The team reports that injecting the AACs they created into infected mice was far more effective at completely wiping out an infection than standard treatments used today. Hardt notes that if the technique proves to be successful in humans, the use of AACs could also mean less development of resistance in bacterial strains because the technique allows for focusing on just one type of bacteria. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Drug-resistant bacteria possess natural ability to become vulnerable to antibiotics More information: Sophie M. Lehar et al. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus, Nature (2015). DOI: 10.1038/nature16057AbstractStaphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clinical failures and relapses after antibiotic therapy. Here we confirm that intracellular reservoirs of S. aureus in mice comprise a virulent subset of bacteria that can establish infection even in the presence of vancomycin, and we introduce a novel therapeutic that effectively kills intracellular S. aureus. This antibody–antibiotic conjugate consists of an anti-S. aureus antibody conjugated to a highly efficacious antibiotic that is activated only after it is released in the proteolytic environment of the phagolysosome. The antibody–antibiotic conjugate is superior to vancomycin for treatment of bacteraemia and provides direct evidence that intracellular S. aureus represents an important component of invasive infections. (Phys.org)—A large team of researchers from several institutions in the U.S. and one in Denmark, working for Genentech, has found that binding an antibiotic to an antibody can be more effective in treating bacterial infections than current methods. In their paper published in the journal Nature, the group describes how their procedure works and the results they found when testing it in mice. Wolf-Dietrich Hardt with the Institute of Microbiology, ETH in Switzerland offers a News & Views piece on the work done by the team and suggests that if the technique proves to work the same way in humans, it could lead to the development of drugs meant to kill infections that are less harmful to good bacteria in the body. Journal information: Nature © 2015 Phys.org Scanning electron micrograph of S. aureus; false color added. Credit: CDC Explore further
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The astronomers, led by Ignazio Pillitteri of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Massachusetts, have used the European Space Agency’s (ESA) XMM-Newton spacecraft to conduct X-ray observations of two regions near Kappa Ori containing young stellar objects (YSO). They detected a total of 121 interesting X-ray sources that appear to be stars with disks, protostars and candidate class III stars. They determined that these YSOs form a distinct star-forming shell between 16 and 26 light years in diameter. Very young stars are very powerful emitters of X-rays. Thus, X-rays are often used to discover young stars embedded in gas and clouds, where optical and infrared observations fail to deliver detailed information. This is because X-rays can penetrate these clouds much better than optical photons.Pillitteri and his colleagues used the X-ray fluxes to compare the emission from stars near Kappa Ori to that in the filamentary dark cloud complex named L1641, observed with the Survey of Orion A with XMM-Newton and Spitzer (SOXS). It was surprising and challenging to discover that there are groups of young stars near Kappa Ori that are significantly more luminous than their siblings in L1641.”In general, the study of the Orion cloud was challenging because recent observations have demonstrated that this ‘nursery’ of stars has a complex structure made of nested bubbles produced by the interaction between the cloud and supernovae explosion or winds from massive stars. My collaborators and I have started to study the Orion A nebula and L1641 in X-rays with SOXS. The research regarding Kappa Ori is a follow-up of that study,” Pillitteri told Phys.org.According to the authors of the paper, the ring of stars with disks is visible in mid-infrared data, as well as in far-infrared and CO line maps. However, the ring is in projection toward the tail of Orion A and the more distant Mon R2 star-forming region; thus, it is not easy to disentangle the single structures along the same line of sight. The existence of this ring yields important information about star formation processes. It supports a scenario in which stellar winds from a massive star at the center of a gas cloud can sweep and compress the gas around it. The gas can then collapse and give birth to stars. Of course, further observations are needed to study this scenario and also to get more insights on these interesting young stellar objects.”There is at least one other field that we want to study, containing a group of young stars with disks. We want to conduct follow-up observations with optical spectroscopy that can be useful to determine photospheric temperatures, gravity, chemical composition and the age of these stars. We also wait for GAIA (Global Astrometric Interferometer for Astrophysics) spacecraft data release that would benefit to study of the whole Orion complex,” Pillitteri concluded.If confirmed by GAIA or other future measurements, this ring will be one of several nested shells found in the Orion-Eridanus superbubble. It could therefore be a great example of star-formation mechanisms where massive stars sweep up the gas and dust in the hot interiors of superbubbles to form shells of cold, star forming gas. (Phys.org)—Astronomers have spotted a star-forming ring around a distant star Kappa Ori, located at the south-eastern corner of the constellation of Orion. The star, also known as Saiph, is a supergiant with a mass of approximately 15 solar masses about 650 light years from Earth. According to the scientists, the newly-detected ring contains several groups of stars. The results were published in a paper on Mar. 1 in the arXiv journal. Far-IR Planck 857 GHz (left panel), mid-IR WISE 12µm (central panel, image from Meisner & Finkbeiner 2014) and velocity integrated CO image (right panel, from CfA CO survey of Dame et al. 2001) around Kappa Ori. Green symbols mark the positions of WISE objects with IR excess. Contours are the footprints of XMM-Newton observations. The dust ring is visible at far-IR and millimeter wavelengths while it appears like a bubble of diffuse emission in mid IR. Credit: Pillitteri et al., 2016. More than meets the eye: Delta Orionis in Orion’s belt Explore further More information: A star forming ring around Kappa Ori 250 pc from the Sun, arXiv:1603.00205 [astro-ph.SR] arxiv.org/abs/1603.00205AbstractX-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here we report on XMM-Newton observations which detect 121 young stellar objects (YSOs) in two fields between L1641S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the young stellar objects detected in the two fields indicates a distance of 250-280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5-8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble, and is unrelated to the southern portion of Orion A / L1641 S. Citation: Star-forming ring spotted around distant supergiant star Kappa Ori (2016, March 11) retrieved 18 August 2019 from https://phys.org/news/2016-03-star-forming-distant-supergiant-star-kappa.html © 2016 Phys.org
© 2016 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (Phys.org)—A team of researchers with the University of California and Stanford University has found that applying “empirical dynamic modeling” techniques to heat and humidity readings over a period of several years revealed some of the factors that cause flu outbreaks to occur. In their paper published in Proceedings of the National Academy of Sciences, the group describes the mathematical modeling techniques they used and what it revealed about the spread of the flu. Link found between influenza, absolute humidity Explore further Citation: Mathematical analysis offers clues on timing of flu outbreaks (2016, November 1) retrieved 18 August 2019 from https://phys.org/news/2016-11-mathematical-analysis-clues-flu-outbreaks.html More information: Global environmental drivers of influenza, PNAS, www.pnas.org/cgi/doi/10.1073/pnas.160774711 Journal information: Proceedings of the National Academy of Sciences Electron microscopy of influenza virus. Credit: CDC Most everyone in places like Europe and the U.S. knows that winter is cold and flu season—but not so clear is when flu is more likely to spread in tropical regions, though scientists have long suspected it is tied to warmer or rainy periods. In this new effort, the researchers applied mathematical models to the problem in an attempt to provide more concrete answers.The researchers used what they describe as an “empirical dynamic modeling framework” to analyze flu outbreak patterns—such time-series models have proven useful in detecting causality in nonlinear systems before (e.g. making connections in anchovy and sardine populations). As possible factors, they used heat and absolute humidity (the actual amount of water in the air), relative humidity (the amount of water in the air relative to temperature) and precipitation amounts over the course of 18 years of flu outbreak data. They report that their models indicate humidity is the strongest environmental factor influencing the spread of the flu, though temperature also plays a part. Interestingly, they found that at temperatures of approximately 70 to 75 degrees, the impact of humidity switches—below that number, drier air supports more flu transmission, but above that mark, more humid air means more flu transmission. The models, the team claims, parallel real-world observations—in places like North America, when the temperature dips below the switch point and humidity levels drop, the flu season starts, but in tropical areas, flu “seasons” typically occur during times when the humidity rises. The results also match with prior research showing that the flu virus tends to swell and burst when exposed to a cold, humid environment and dries up when things get hot and dry.These findings, the team suggests, means that simply adding humidifiers to homes in temperate climates and running them during the cold months might actually slow the spread of an outbreak.
Delhi has no dearth of great places to eat, but here’s a lowdown. Seven restaurants have been picked out for Restaurant Week India and foodies can be rest assured that they will not be disappointed. Scheduled for 23 September to 2 October, Restaurant Week India (RWI) is on its seventh round in the country. Restaurant Week originated in New York in 1992 and is now held in various cities in Europe, South America and even South East Asia.This year’s run of RWI includes Dakshin, Diva, Diva Kitsch, Sevilla, Pan Asian, Le Riviera and Prego. These restaurants will be offering a three-course prix fixe menu at Rs 1000 for lunch and Rs 1200 for dinner. Dakshin was our pick for the preview for RWI. The restaurant at Sheraton has enough awards in its kitty to make a statement. Also Read – ‘Playing Jojo was emotionally exhausting’Known for cuisines from the south of the country, Dakshin dishes out a mean fare with some excellently done dishes. The pan fried fish is one of the dishes which gets all our votes. The simple but delectable vegetable stew that goes best with appams is a must try. Then of course there are the soft Malabar paranthas which go very well with the spicier non vegetarian dishes. We also tried the spicy dry lamb which the restaurant recommended as one of their top picks. Also Read – Leslie doing new comedy special with NetflixThe best part of the Dakshin experience was the open kitchen where appams are made right in front of you. The authentic south Indian coffee is also a must in Dakshin. And yes, the completely awesome serving of papads that Dakshin along with some incredible chutneys. It is almost impossible to keep your hands off them even after the food arrives. Keep up with us as RWI starts on good and proper by end of this month and as a reminder – general reservations for RWI starts online from 18 September. Go book your tables.
Mar Thoma Syrian Church of Malabar Delhi Diocese is all set to hold an annual Christmas Celebrations- “Gloria in Excelsis” on December 13 at Weight lifting Auditorium, Jawaharlal Nehru Stadium, (Near Gate No.1), Lodhi Road. Gloria in Excelsis is a mega Christmas Event organized by the Diocese of Delhi of the Mar Thoma Church, conceived and designed to help, mitigate the brutal exploitation of fellow human beings. For the last five years this musical concert is organized by the Diocese of Delhi as a Christmas gift to the capital city. Also Read – ‘Playing Jojo was emotionally exhausting’The event will be inaugurated by Rt. Rev. Dr. Abraham Mar Paulos Episcopa and the chief guest for the evening will be Sharmila Tagore, the Goodwill Brand Ambassador of UNICEF. The concert will also be featuring the alternative music band from Kerala, Avial. Through this event the Delhi Diocese sends a strong message that the Church walks with the people especially those who are marginalised. Through this year’s event, with the theme “Return to Innocence” the church would like to show its solidarity towards the abused childhood and sensitize the society about the problem as the issue of ‘Child abuse’ has become rampant and a cause of high alert. Also Read – Leslie doing new comedy special with NetflixThrough the event, the church would like to remind and sensitize the society about child abuse and initiate projects and events to reduce the rate of abuse. Besides these the Church would like to stand with the abused in whatever ways it can. The church encompasses nearly the length and breadth of Northern India, spreading across 18 states.When: December 13Where: Jawaharlal Nehru Stadium Complex, Weight Lifting Auditorium (Near Gate No.1), Lodhi Road
Kolkata: Bangladesh Prime Minister Sheikh Hasina and Chief Minister Mamata Banerjee had a 45-minute closed-door meeting on Saturday holding discussions on wide-ranging topics including education, business and culture. “We discussed our education, culture, business for the well-being of the people of both the countries. We share a very cordial relationship and as far as I understand, there is no political boundary between the two nations. We love each other and whenever we have to, we interact with each other openly,” Banerjee said after the talks at a South Kolkata star hotel where Sheikh Hasina was staying. Also Read – Heavy rain hits traffic, flightsSpeaking on a museum being set up in the city in memory of Sheikh Mujibur Rahman, she said: “They have a space on Theatre Road which is under Aurobindo Bhavan. They want to restore it and work for it can be taken on the basis of discussions between the two countries.”It is learnt that Banerjee had urged Hasina to visit Bengal again. “They can come here anytime they wish to and we will also go there so that the good relationship is further strengthened,” Banerjee said. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedWishing prosperity for Bangladesh, she maintained that her relationship with Hasina is at the personal level that has been there for a very long time even when she was the Leader of Opposition in Bangladesh. “I know all her family members and our relationship will continue to grow,” she said. She expressed her gratitude to Hasina for accepting the D.Litt award that was conferred to her by Kazi Nazrul University earlier in the day. “We had wished to honour her and she had made us proud by accepting it,” she added. Meanwhile, the Bangladesh Prime Minister also visited Netaji Bhawan in Kolkata. “Had there not been the armed struggle by Netaji Subhas Bose, India would not have achieved independence,” she said after her first visit to Netaji Bhawan. “The liberation war of Bangladesh was also inspired by Netaji’s freedom movement. And this I came to know from our great leader Banga Bandhu’s tapes. I am grateful to my sister Rehana who insisted on visiting Netaji Bhawan together,” she added.
Kolkata: Trinamool Congress organised protests over the hike in the price of petrol and diesel at different parts of the state, including Birbhum, on Wednesday.It may be mentioned that Trinamool Congress MP and President of the party’s youth wing, Abhishek Banerjee, had protested against the abnormal hike in the prices of petrol and diesel on Tuesday, at Gandhi statue in Kolkata.On Wednesday, Trinamool Congress workers held rallies at different places, protesting against the same. Also Read – Heavy rain hits traffic, flightsIt may be recalled that it was Chief Minister Mamata Banerjee, who was the first to raise her voice protesting against the hike in prices of petrol and diesel. She had tweeted stating that the hike in the prices of petrol and diesel would also lead to an increase in the prices of essential commodities. Common people also participated in the protest rallies held in different parts of the state. At many places, local people and party supporters staged sit-in-demonstrations and shouted slogans against the BJP government at the Centre for “its indifference” in this connection. They demanded immediate intervention of the Centre to ensure a drop in the prices of petrol and diesel. It may be mentioned that with prices of diesel remaining high for almost two weeks now, the cost of essential goods are now starting to go up. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedThe truck owners have expressed their helplessness in continuing to transport goods at previous rates and have started charging high as the fuel prices have gone up. “Automatically, the cost of all sorts of goods is going up and common people have to suffer for the same,” said Puspa Naskar, who sells vegetables at a local market in the city.She further said the increase in the prices of fuel will also affect their business, as the sale of goods will go down with increase in prices.
Kolkata: The Special Task Force of Kolkata Police has arrested one person on the charge of possessing fake Indian currency with a total face value of Rs four lakh, an STF officer said on Friday. Accused Sattar Sheikh, 47, is a resident of Jharkhand’s Jamnagar area.He was arrested from the south-east gate of North Bengal State Transport Corporation (NBSTC) bus stand near Maidan in central Kolkata on Thursday evening. “As many as 200 notes in Rs 2,000 denomination were seized from him, hidden inside a specially designed underwear he was wearing,” the officer said.Sheikh was booked under Section 120B (criminal conspiracy) of the Indian Penal Code, apart from Sections 489A, B and C, he said.The accused will be presented in a sessions court here later on Friday.
Kolkata: Renowned playwright Ratan Thiyam today advocated the introduction of music in the curriculum of schools and colleges. The Padma Shri winner said in order to “save” music and educate our younger generation, it should be presented in different ways. “It is (introducing music in educational institutions as curriculum) very important but not happening everywhere,” he told reporters here. Thiyam, however, said he was not specifically referring to traditional or modern music, but music of different genres. Also Read – Rain batters Kolkata, cripples normal life He was speaking to reporters on the sidelines of the three-day “root music” festival ‘Sahaj Parav’, in which over 100 artistes representing different genres of traditional music are participating. “Music is music. One has to identify music within himself (in whatever genre that may be)… from South, Rajasthan or from any other place in the country,” Thiyam said. He said music has the power to make a person happy and cheerful. “Pure music will penetrate the heart of a person… Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killed You listen to Rabindra Sangeet when you are in a very depressed mood, and then suddenly you see the song is washing way your depression. It is very important to love music, which can sink differences and unify the country,” Thiyam, also a recipient of the Sangeet Natak Akademi Award, said. About the festival, he said it is very important to realise the importance of roots. “As the force of globalisation is really picking up and there is the dangerous phenomenon which one can see about one gradually losing his identity, your roots have to be very strong,” he said. West Bengal Minister of State for Cultural Affairs Indranil Sen, who also present on the occasion, said his department will extend all cooperation to the organisers of the ‘Sahaj Parav’ festival – Lopamudra Foundation and Dohar – in organising folk music festivals in 341 blocks, if they wanted it. Sen said 1,94,000 folk artistes were now getting monthly stipend from the state government, as part of the initiative to promote folk music. “Unlike the previous regime, we don’t bring the folk musicians to hold a big rally once in a year and then forget all about them. We are committed in improving their economic conditions,” he added.